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by Joseph A. Beavo,Sharron H. Francis,Miles D. Houslay

Download Cyclic Nucleotide Phosphodiesterases in Health and Disease eBook
ISBN:
0849396689
Author:
Joseph A. Beavo,Sharron H. Francis,Miles D. Houslay
Category:
Medicine
Language:
English
Publisher:
CRC Press; 1 edition (December 5, 2006)
Pages:
728 pages
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1238 kb
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1148 kb
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1686 kb
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Since the last major compendium dedicated to cyclic nucleotide phosphodiesterases (PDEs) was published over 15 years ago, an enormous amount of progress has occurred in the field

Since the last major compendium dedicated to cyclic nucleotide phosphodiesterases (PDEs) was published over 15 years ago, an enormous amount of progress has occurred in the field. Cyclic Nucleotide Phosphodiesterases in Health and Disease provides an integrated volume covering PDE biology from genes to organisms. It examines phosphodiesterases as pharmacological targets as well as the development of specific PDE inhibitors as therapeutic agents.

Joseph A. Beavo, Sharron H. Francis, Miles D. Houslay. She obtained her undergraduate degree with emphasis in biology and chemistry from the Western Kentucky State in Bowling Green; studies for her doctoral degree in physiology were performed at Vanderbilt University under the guidance of Jane Park, PhD.

Since the last major compendium dedicated to cyclic nucleotide phosphodiesterases (PDEs) was published over 15 years ago, an. .

Since the last major compendium dedicated to cyclic nucleotide phosphodiesterases (PDEs) was published over 15 years ago, an enormous amount of progress ha. First Published 2006.

Cyclic Nucleotide Phosphodiesterase Superfamily, J. A. Beavo, M. D. Houslay, and S. H. Francis Phosphodiesterase Isoforms-An Annotated List, G. B. Bolger Section A Specific Phosphodiesterase Families-Regulation, Molecular and Biochemical Characteristics. Bolger Section A Specific Phosphodiesterase Families-Regulation, Molecular and Biochemical Characteristics d Cyclic Nucleotide Phosphodiesterases, A. T. Bender PDE2 Structure and Functions, S. E. Martinez Phosphodiesterase 3B: An Important Regulator of Energy Homeostasis, E. Degerman and V. Manganiello Cellular.

ISBN-13: 978-0849396687.

Beavo, Joseph; Sharron Francis; Miles Houslay (2010). Cyclic Nucleotide Phosphodiesterases in Health and Disease. Boca Raton, FL: CRC Press. p. 546. ISBN 9780849396687. Sutherland, Earl; Robison GA; Butcher RW (1968). Some aspects of the biological role of adenosine 3',5'-monophosphate (cyclic AMP)". Lincoln, TM; Cornwell TL (1991).

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Francis et al. Zoraghi R, Bessay EP, Corbin JD, Francis SH (2005) Structural and functional features in hu- man PDE5A1 regulatory domain that provide for allosteric cGMP binding, dimerization, and regulation. J Biol Chem 280(12):12051–12063 Zoraghi R, Francis SH, Corbin JD (2007) Critical amino acids in phosphodiesterase-5 catalytic site that provide for high-affinity interaction with cGMP and inhibitors. Biochemistry 46: 13554–13563. cGMP-Dependent Protein Kinase Modulators Elke Butt Contents 1 Introduction. 410 . Cyclic Nucleotide Analogs .

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You will learn about Cyclic Nucleotide Phosphodiesterases in Health and Disease by Joseph A.

Since the last major compendium dedicated to cyclic nucleotide phosphodiesterases (PDEs) was published over 15 years ago, an enormous amount of progress has occurred in the field. There is great need for a centralized source for key information in this burgeoning and therapeutically important area of medical research.

Cyclic Nucleotide Phosphodiesterases in Health and Disease provides an integrated volume covering PDE biology from genes to organisms. It examines phosphodiesterases as pharmacological targets as well as the development of specific PDE inhibitors as therapeutic agents. With contributions from pioneers in the field, individual chapters describe one of the 11 known mammalian PDE families including the molecular characteristics, structure, function, and traits unique to each. Characteristics of PDEs from lower organisms are also the subject of other chapters since they provide key insights into PDE functions and are also pharmacological targets for treatment of a variety of diseases in humans and domestic animals. Chapters on the current biomedical and therapeutic research on PDEs include studies on gene-targeted knockout strategies and compartmentation in cyclic nucleotide signaling. By unraveling the unique cellular roles for different PDEs, scientists are beginning to open the door to the therapeutic use of PDE inhibitors for the treatment of a number of pathological conditions including asthma and inflammation, pulmonary hypertension, erectile dysfunction, and stroke.

By collating current information into a coherent and coordinated perspective, Cyclic Nucleotide Phosphodiesterases in Health and Disease provides an invaluable reference for industry and clinical scientists and points toward future directions of research and therapeutic advancements in developing selective inhibitors for these various enzymes.