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by Keshav Singh,Leslie Costello

Download Mitochondria and Cancer eBook
ISBN:
1441927387
Author:
Keshav Singh,Leslie Costello
Category:
Medicine
Language:
English
Publisher:
Springer; Softcover reprint of hardcover 1st ed. 2009 edition (October 29, 2010)
Pages:
289 pages
EPUB book:
1759 kb
FB2 book:
1112 kb
DJVU:
1321 kb
Other formats
doc docx mbr rtf
Rating:
4.6
Votes:
550


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Mitochondria and Cancer. An exhaustive analysis of the role of mitochondria in cancer, this book surveys the Warburg Hypothesis, mitochondrial structure and function, and then outlines the metabolic and molecular alterations in mitochondria that are associated with human cancer.

Finding books BookSee BookSee - Download books for free. Mitochondria and Cancer. Category: Медицина, Онкология.

He is the Joy and Bill Harbert Endowed Chair, Professor of Genetics, Pathology and Environmental Health and the Director of the Cancer Genetics Program at the University of Alabama at Birmingham (UAB). Keshav K. Singh, Leslie C. Cos. Includes bibliographical references and index. Published 2009 by Springer in New York.

Contrary to conventional wisdom, functional mitochondria are essential for the cancer cell. Although mutations in mitochondrial genes are common in cancer cells, they do not inactivate mitochondrial energy metabolism but rather alter the mitochondrial bioenergetic and biosynthetic state. These states communicate with the nucleus through mitochondrial 'retrograde signalling' to modulate signal transduction pathways, transcriptional circuits and chromatin structure to meet the perceived mitochondrial and nuclear requirements of the cancer cell

The book begins with a general overview of Warburg Hypothesis, mitochondrial structure and function, and then outline more specifically the metabolic and molecular alterations in mitochondria that are associated with human cancer and their clinical implications.

Singh, Keshav K. Walmart 9780387848341. The book begins with a general overview of Warburg Hypothesis, mitochondrial structure and function, and then outline more specifically the metabolic and molecular alterations in mitochondria that are associated with human cancer and their clinical implications. An emphasis is also placed on mtDNA mutations and their potential role in carcinogenesis. The potential use of mitochondria as biomarkers for early detection of cancer, or as unique cellular targets for novel and selective anti-cancer agents will also be discussed.

Mitochondrial Electron Transport Chain. Dr. Michael R. Eades says, As the high-energy electrons are passed along down the inner mitochondrial membrane they occasionally break free. When they break free, they become free radicals. These rogue free radicals can then attack other molecules and damage them

Keshav Singh, Leslie Costello - Mitochondria and Cancer.

Keshav Singh, Leslie Costello - Mitochondria and Cancer. Leslie C. Orr. Читать pdf.

An exhaustive analysis of the role of mitochondria in cancer, this book surveys the Warburg Hypothesis, mitochondrial structure and function, and then outlines the metabolic and molecular alterations in mitochondria that are associated with human cancer.